Diagnosis and Interventions
Vaccines
Active Awards
Leveraging Early Adolescence to Prevent TB (LEAP trial) - Drs. Lisa Marie Cranmer and Cheryl Day
Identifying critical determinants of vaccine-induced cellular and humoral immunity from birth through childhood in HIV-exposed and unexposed children: Dr. Cheryl Day
Estimating the Epidemiologic Impact of TB Vaccines using Mathematical Models: Dr. Kristin Nelson
Completed Awards
Novel Nanoparticle Respiratory Tract Mucosal Vaccine: Dr. Frederick Quinn
The role of antibodies in infant TB prevention: Dr. Lisa Cranmer
Diagnostics
Active Awards
Immunometabolic Biomarkers to Advance TB Diagnosis and Treatment Monitoring: Dr. Jeffrey Collins
PROgression of Tuberculosis infECTion in young children living with and without HIV: the PROTECT study: Dr. Jeffrey Collins
Microscale Multiplexed Antibody Fc Profiling and Nanoscale Electronic Detection for Rapid and Scalable Point-of-Care Diagnosis of Tuberculosis: Dr. Aniruddh Sarkar
Leveraging antibody-omics to prevent and detect TB in children affected by HIV: Drs. Lisa Marie Cranmer and Aniruddh Sarkar
Completed Awards
High-Resolution Plasma Metabolomic Profiling to Identify Biomarkers for Tuberculosis Disease and Response to Therapy: Drs. Tom Ziegler and Dean Jones
High resolution plasma metabolomics to identify biomarkers of tuberculosis: Dr. Jeffrey Collins
Childhood ‘Omics’ and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings: Drs. Jeff Collins and Tom Ziegler
Integrated computer-aided, point-of-care ultrasound for tuberculosis screening: Dr. Anant Madabhushi
Treatment
Active AwardsAI-MedWise: Developing and validating an artificial intelligence solution for effective video-based monitoring of medication adherence: Drs. Juliet Sekandi and Jin Sun
Therapeutic drug monitoring for linezolid in the treatment of rifampin-resistant tuberculosis: a pragmatic randomized controlled trial: Drs. James Brust and Neel Gandhi
AIDS Clinical Trials Group Laboratory Center – Delamanid Supplement: Dr. Sarita Shah
The role of tyrosine metabolism in tuberculosis pathogenesis: Dr. Jeffrey Collins
dsRNA regulation of the cytosolic innate immune system: Dr. Graeme Conn
Completed Awards
Synthetic Nanoparticle-antibody (SNAb) Based Depletion of Myeloid-Derived Suppressor Cells for TB Host-Directed Therapy: Drs Jyothi Rengarajan and Roy Krishnendu
Emergence of bedaquiline, pretomanid and linezolid resistance after implementation of new drug-resistant tuberculosis regimens in South Africa: Drs. James Brust and Neel Gandhi
Cavity and Granuloma Oriented Inflammation and Tissue Pharmacokinetics in Pulmonary Tuberculosis (COOK TB): Dr. Russell Kempker
A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR Tuberculosis: Dr. Russell Kempker
An Exploratory Study of Anti-Tuberculosis Drug Penetration into Cerebrospinal Fluid: Dr. Russell Kempker
Intra Cavitary Pharmacokinetics and Drug Resistance in Pulmonary Tuberculosis: Dr. Russell Kempker
Impact of HIV, Antiretroviral Therapy and TB Genotype on Survival in MDR TB: Dr. Neel Gandhi
RNA modification and antibiotic resistance: Drs. Graeme Conn and Christine Dunham
Efficacy and Tolerability of Levofloxacin in Combination with Optimized Background Regimen for the treatment of MDR-TB (Opti-Q Trial/TB Trials Consortium Study 32): Dr. Neel Gandhi
Development of Gleevec for TB and TB/HIV: Dr. Daniel Kalman
CDC Tuberculosis Epidemiologic Studies Consortium: Drs. Henry Blumberg, Marcos Schechter, and Russell Kempker
Targeted pan-antibacterial liposomes to control pathogenic mycobacteria: Dr. Richard Meagher